- Title
- Thyroid antibodies, autoimmunity and cognitive decline: is there a population-based link?
- Creator
- Napthali, K.; Boyle, M.; Tran, H.; Schofield, P. W.; Peel, R.; McEvoy, M.; Oldmeadow, C.; Attia, J.
- Relation
- Dementia and Geriatric Cognitive Disorders. Extra Vol. 4, Issue 2, p. 140-146
- Publisher Link
- http://dx.doi.org/10.1159/000362716
- Publisher
- Karger
- Resource Type
- journal article
- Date
- 2014
- Description
- Background: Autoimmunity is considered an uncommon but under-recognised cause of cognitive decline. Methods: Serum samples from 3,253 randomly selected subjects enrolled in the Hunter Community Study, aged 55-85 years, were assayed for thyrotropin stimulatory hormone, anti-thyroid peroxidase antibodies (TPO-Ab), anti-nuclear antibodies (ANA) and extractable nuclear antigens (ENA). Cognitive function was assessed using the Audio Recorded Cognitive Screen (ARCS) tool. Results: TPO-Ab were found in 8.4% and ANA in 27.9% of the study population, of whom 3% had positive ENA findings. No relationship was found between the ARCS score and either TPO-Ab (coefficient = 0.133; 95% CI -0.20, 0.82, p = 0.616), ANA at a low (coefficient = 1.01; 95% CI -2.58, 0.55, p = 0.203) or a high titre (coefficient = -0.65; 95% CI -2.59, 1.28, p = 0.508), or ENA antibodies (coefficient = 5.12; 95% CI -0.53, 10.77; p = 0.076). Conclusions: Autoantibody findings are common in an aging population and are not associated with cognitive decline.
- Subject
- dementia; hashimoto disease; encephalitis; autoantibodies; anti-nuclear antibodies; nuclear antigens; autoimmune thyroiditis; mild cognitive impairment
- Identifier
- http://hdl.handle.net/1959.13/1294541
- Identifier
- uon:18825
- Identifier
- ISSN:1664-5464
- Language
- eng
- Full Text
- Reviewed
- Hits: 5002
- Visitors: 5213
- Downloads: 297
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 875 KB | Adobe Acrobat PDF | View Details Download |